DLL4 Human, Fc Human, Recombinant, Human (Delta-like Protein 4, Delta4)
Catalog No : USB-044756
487.37€
0.00€
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| Product name | DLL4 Human, Fc Human, Recombinant, Human (Delta-like Protein 4, Delta4) | ||
|---|---|---|---|
| Catalog No | USB-044756 | ||
| Supplier’s Catalog No | 044756 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, Human, HEK 293 cells | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 80 | ||
| Storage | 4°C/-20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | >95% (SDS-PAGE) | ||
| Form | Supplied as a lyophilized powder in PBS, pH 7.2, 0.5% Trehalose. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | >95% (SDS-PAGE) | ||
| Description | The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, promoting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina. Biological Activity: Inhibits adipogenesis of 3T3L-1 cells and mesenchymal stem cells (MSCs). Induces Hes-1 in 3T3L-1 cells. Sequence: Signal peptide and extracellular domain of human DLL4 (aa 1-529) are fused at the C-terminus to the Fc portion of human IgG1. Storage and Stability: Short-term Storage: +4°C Long-term Storage: -20°C Working aliquots are stable for up to 3 months when stored at -20°C. | ||
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