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Categories: Peptides & Proteins / Proteins

Product name			Jagged-1, Recombinant, Mouse,Fc Human (Protein Jagged-1, CD339, JAG1)
Catalog No			USB-044969
Supplier’s Catalog No			044969
Supplier			US Biologicals
Source antigen			Recombinant, HEK 293 cells
Reactivity
Cross reactivity
Applications
Molecular weight			150

Storage			-20°C
Other names
Grade			Purified
Purity			≥90% (SDS-PAGE). Endotoxin: ≤0.01EUug (LAL)
Form			Supplied as a liquid in PBS, pH 7.2.
Reactivity life			6 months
Note			For reserch purpose only
Purity			≥90% (SDS-PAGE). Endotoxin: ≤0.01EUug (LAL)
Description			Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF). Biological Activity: Inhibits adipogenesis of 3T3L-1 cells Sequence: Signal peptide and extracellular domain of mouse Jagged-1 (aa1-1067) are fused at the C-terminus to the Fc portion of human IgG. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.