Jagged-1 (Human):Fc (Human), Recombinant (Protein Jagged-1, hJ1, CD339, JAG1)
Catalog No : USB-044970
466.68€
0.00€
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| Product name | Jagged-1 (Human):Fc (Human), Recombinant (Protein Jagged-1, hJ1, CD339, JAG1) | ||
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| Catalog No | USB-044970 | ||
| Supplier’s Catalog No | 044970 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, Human, HEK 293 cells | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 150 | ||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ≥90% (SDS-PAGE). Endotoxin: ≤0.01EUug (LAL) | ||
| Form | Supplied as a 0.2um-filtered solution in PBS, pH 7.2. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ≥90% (SDS-PAGE). Endotoxin: ≤0.01EUug (LAL) | ||
| Description | Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF). Biological Activity: Inhibits adipogenesis of mesenchymal stem cells (MSCs). Induces Hes-1 in 3T3L-1 cells. Sequence: Signal peptide and extracellular domain of human Jagged-1 (aa 1-1067; UniProt accession #P78504) are fused at the C-terminus to the Fc portion of human IgG1. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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