Nucleophosmin, Recombinant, Human, GST-tag (hNPM, Nucleolar Phosphoprotein B23, Nucleolar Protein NO38, Numatrin, NPM, NPM1)
Catalog No : USB-220112
474.73€
0.00€
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| Product name | Nucleophosmin, Recombinant, Human, GST-tag (hNPM, Nucleolar Phosphoprotein B23, Nucleolar Protein NO38, Numatrin, NPM, NPM1) | ||
|---|---|---|---|
| Catalog No | USB-220112 | ||
| Supplier’s Catalog No | 220112 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 59.8 | ||
| Storage | -70°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~95% (SDS-PAGE) | ||
| Form | Supplied as a liquid in 25mM Tris, pH 8.0, 20% glycerol. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95% (SDS-PAGE) | ||
| Description | Nucleophosmin is a nucleus protein which belongs to the nucleoplasmin family. It is a nucleolar phosphoprotein that shuttles between the nucleus and cytoplasm during the cell cycle. Nucleophosmin/NPM1 is involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors TP53/p53 and ARF. Subcellular localization of Nucleophosmin/NPM1 appears to be strongly correlated with NPM1 functions and cell proliferation. It is phosphorylated mainly at its central acidic domain by several upstream kinases, and its phosphorylation appears to be involved in regulating its functions in ribosome biogenesis and centrosome duplication. Nucleophosmin/NPM1 binds ribosome presumably to drive ribosome nuclear export. It is associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Nucleophosmin/NPM1 acts as a chaperonin for the core histones H3, H2B and H4. Nucleophosmin may act as a licensing factor to maintain proper centrosome duplication and that the Ran/CRM1 nucleocytoplasmic complex regulates local trafficking of Nucleophosmin/NPM1 to centrosomes by interacting through its nuclear export sequence motif. Source: Recombinant protein corresponding to 292aa from human Nucleophosmin, fused to GST-tag at N-terminal, expressed in E. coli. Molecular Weight: ~59.8kD (292aa + NT GST-tag) Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | ||
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