Nucleosomes
Catalog No : USB-137315
721.86€
0.00€
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| Product name | Nucleosomes | ||
|---|---|---|---|
| Catalog No | USB-137315 | ||
| Supplier’s Catalog No | 137315 | ||
| Supplier | US Biologicals | ||
| Source antigen | Mammalian HEK293 cells | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | |||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~90% (Coomassie) | ||
| Form | Supplied as a liquid. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ~90% (Coomassie) | ||
| Description | A nucleosome is a section of DNA that is wrapped around a core of proteins. Inside the nucleus, DNA forms a complex with proteins called chromatin, which allows the DNA to be condensed into a smaller volume. When the chromatin is extended and viewed under a microscope, the structure resembles beads on a string. Each of these tiny beads is a called a nucleosome and has a diameter of approximately 11 nm. The nucleosome is the fundamental subunit of chromatin. Each nucleosome is composed of a little less than two turns of DNA wrapped around a set of eight proteins called histones, which are known as a histone octamer. Each histone octamer is composed of two copies each of the histone proteins H2A, H2B, H3, and H4. The chain of nucleosomes is then compacted further and forms a highly organized complex of DNA and protein called a chromosome. Source: Nucleosomes prepared from mammalian HEK293 cells as a substrate for histone methyltransferase assay. Applications: Suitable for use in Histone methyltransferase assay and screening small molecular inhibitors of histone methyltransferases for drug discovery and HTS applications. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | ||
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