Leptin, Recombinant, Mouse (Ob, Obese Protein, Obesity Factor)
Catalog No : USB-L1670-10
354.03€
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| Product name | Leptin, Recombinant, Mouse (Ob, Obese Protein, Obesity Factor) | ||
|---|---|---|---|
| Catalog No | USB-L1670-10 | ||
| Supplier’s Catalog No | L1670-10 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 16.2 | ||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | ≥ 95% by SDS-PAGE and HPLC. Endotoxin: ≤ 0.1ng/ug. | ||
| Form | Supplied as a lyophilized powder from 0.1% TFA. Reconstitute with sterile dH2O to a concentration of 1-5mg/ml. This solution can then be diluted into other aqueous solutions. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ≥ 95% by SDS-PAGE and HPLC. Endotoxin: ≤ 0.1ng/ug. | ||
| Description | Leptin (Anti-Obesity Protein) is the protein product of the ob (obese) gene in mice and seems to be involved in appetite control. The ob gene is expressed in adipose tissue and is thought to regulate the body's fat stores. Mice with the ob/ob genotype also develop a form of diabetes similar to type II (non-insulin dependent) diabetes. Recombinant murine leptin is a 16.2kD protein containing 147 amino acid residues. Biological Activity: Murine leptin has been shown to be biologically active in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5ug leptin/g of body weight for 7 days. Significant effects on body weight, food consumption and plasma glucose levels were observed compared to saline-treated controls. Amino Acid Sequence: MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSAKQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND LENLRDLLHL LAFSKSCSLP QTSGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDVSPEC Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile dH2O and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Country of Origin: USA | ||
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