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Categories: Peptides & Proteins / Proteins

Product name			Leptin, Recombinant, Human (Ob, Obese Protein, Obesity Factor)
Catalog No			USB-L1670-15J
Supplier’s Catalog No			L1670-15J
Supplier			US Biologicals
Source antigen			Recombinant, Human
Reactivity
Cross reactivity
Applications
Molecular weight			16

Storage			4°C/-20°C
Other names
Grade			Highly Purified
Purity			≥95% by SDS PAGE
Form			Supplied as a liquid in PBS, pH 7.4
Reactivity life			6 months
Note			For reserch purpose only
Purity			≥95% by SDS PAGE
Description			Human leptin is a 16kD nonglycosylated hormone that is produced in mature adipocytes. Leptin acts primarily in the hypothalamus to reduce food intake and body weight. In ob/ob mice, the gene encoding leptin is mutated, resulting in morbid obesity and associated abnormalities, including hyperphagia, hypothermia, diabetes and infertility. The function of leptin in regulating appetite and metabolism, as well as the possibility of using leptin as a therapeutic agent, are currently under intense investigation. Recombinant human leptin was overexpressed as insoluble protein aggregate in E. coli and purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. Molecular Weight: 16kD (147amino acids) Sequence: MVPIQKVQDD/ TKTLIKTIVT/ RINDISHTQS/ VSSKQKVTGL/ DFIPGLHPIL/ TLSKMDQTLA/ VYQQILTSMP/ SRNVIQISND/ LENLRDLLHV/ LAFSKSCHLP/ WASGLETLDS/ LGGVLEASGY/ STEVVALSRL/ QGSLQDMLWQ/ LDLSPGC Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.