GPR39, Control Peptide (G-Protein Coupled Receptor 39, GPCR39)
Catalog No : USB-G8600-43J
417.25€
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| Product name | GPR39, Control Peptide (G-Protein Coupled Receptor 39, GPCR39) | ||
|---|---|---|---|
| Catalog No | USB-G8600-43J | ||
| Supplier’s Catalog No | G8600-43J | ||
| Supplier | US Biologicals | ||
| Source antigen | Synthetic peptide | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 3 | ||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Purified | ||
| Purity | Purified | ||
| Form | Supplied as a lyophilized powder from PBS, 0.05% sodium azide. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | Purified | ||
| Description | Control peptide for G8600-43C (affinity purified) and G8600-43K (antiserum). Control of appetite involves a number of gastrointestinal hormones that belong to the ghrelin-motilin ligand family that either stimulate food intake and gastric emptying or inhibit these responses. These hormones have been the focus of intense research in hopes of developing drug therapy for gastrointestinal and eating disorders. GPR39 is a G protein-coupled receptor (GPCR). It is sequentially distantly related to the growth hormone secretagogue receptor (ghrelin) and neurotensin receptors. Its endogenous ligand was unknown until 2005, when an amidated 23aa peptide, obestatin, was found to bind to it specifically. Interestingly, these two peptides appear to have opposite effects. While ghrelin stimulates appetite by acting on its receptor in the arcuate nucleus, obestatin suppresses appetite. GPR39 mouse: 456aa; human: 453aa -51kD; Chromosome: 2q21-q22. Expressed in many tissues and brain regions. GPR39 is alternatively spliced. Full length GPR39-1a (456aa in mouse with 7 TM domains) and truncated form (GPR39-1b; 315aa with 5 TM domains). Quantitative RT-PCR analysis demonstrated that GPR39-1a is expressed selectively throughout the gastrointestinal tract, including the liver and pancreas as well as in the kidney and adipose tissue, whereas the truncated GPR39-1b form has a more broad expression pattern, including the central nervous system but with highest expression in the stomach and small intestine. Source: Synthetic peptide corresponding to 19aa of human GPR392 (Accession #O43194), N-terminal, extracellular. Molecular Weight: ~3kD Applications: Suitable for use in ELISA and Antibody Blocking. Not suitable for Western Blot. Other applications not tested. Recommended Dilution: ELISA: 5-10ug control peptide per 1ug of aff pure IgG or 1ul antiserum Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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