Imugex

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Categories: Peptides & Proteins / Proteins

Product name			MUSK, Recombinant, Human, GST-Tag (Muscle/Skeletal Receptor Tyrosine Protein Kinase)
Catalog No			USB-500287
Supplier’s Catalog No			500287
Supplier			US Biologicals
Source antigen			Recombinant, Insect cells
Reactivity
Cross reactivity
Applications
Molecular weight			63

Storage			-70°C
Other names
Grade			Purified
Purity			Purified (~70-90%)
Form			Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 150mM sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Reactivity life			6 months
Note			For reserch purpose only
Purity			Purified (~70-90%)
Description			MUSK is a receptor tyrosine kinase necessary for neuromuscular junction formation. MUSK gene expression is highly regulated during neuromuscular junction and it is involved in intercellular communication present on the surface of cells that are activated by specific protein ligands. MUSK members play a key role in growth and differentiation of those cell types. Agrin signals through MUSK to cluster acetylcholine receptors on the postsynaptic membrane of the neuromuscular junction. DOK7, a MUSK-interacting cytoplasmic protein, is essential for MUSK activation in cultured myotubes. MUSK also plays a critical role in the development of normal blood vessels. Source: Recombinant protein corresponding to human MUSK, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~63kD Specific Activity: 6.7nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.