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Categories: Peptides & Proteins / Proteins

Product name			TRKA, Recombinant, Human, GST-Tag (Tyrosine Kinase Receptor A, Nerve Growth Factor Receptor, NTRK1, MTC, TRK, TRK1, p140-TrkA)
Catalog No			USB-500515
Supplier’s Catalog No			500515
Supplier			US Biologicals
Source antigen			Recombinant, Insect cells
Reactivity
Cross reactivity
Applications
Molecular weight			66

Storage			-70°C
Other names
Grade			Purified
Purity			Purified (~70-90%)
Form			Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 150mM sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Reactivity life			6 months
Note			For reserch purpose only
Purity			Purified (~70-90%)
Description			TRKA is a member of the trk proto-oncogene family and encodes a 140kD, membrane-spanning protein tyrosine kinase that is the functional receptor for nerve growth factor (NGF). NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues leading to increased c-Fos expression, DNA synthesis and morphologic transformation. A decreased expression of TRKA on the striatal cholinergic neurons has been observed which may contribute, when it reaches a crucial threshold, to the death of cholinergic neurons observed in Alzheimer disease. Source: Recombinant protein corresponding to human TRKA, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~66kD Specific Activity: 22nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.