EPHB4, Recombinant, Human, aa16-539, His-Tag (Ephrin Type-B Receptor 4, HFASD, HTK, MYK1, TYRO11)

Catalog No : USB-506169
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Product name EPHB4, Recombinant, Human, aa16-539, His-Tag (Ephrin Type-B Receptor 4, HFASD, HTK, MYK1, TYRO11)
Catalog No USB-506169
Supplier’s Catalog No 506169
Supplier US Biologicals
Source antigen Recombinant, Baculovirus
Reactivity
Cross reactivity
Applications
Molecular weight 58.1532507
Storage -20°C/-70°C
Other names
Grade Highly Purified
Purity >90% (SDS-PAGE)
Form Supplied as a liquid in PBS, pH 7.4, 10% glycerol.
Reactivity life 6 months
Note For reserch purpose only
Purity >90% (SDS-PAGE)
Description EPHB4, also known ephrin type-B receptor 4, is a member of the Eph receptor tyrosine kinase family. It binds transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. This protein plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. And the signaling of this protein controls cellular repulsion and segregation form EFNB2-expressing cells. And it also plays a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. Description: Recombinant protein corresponding to aa16-539 of human EPHB4, fused to His-tag at C-terminus, expressed in Baculovirus Molecular Weight: ~58.1kD (532aa), ~50-70kD (SDS-PAGE under reducing conditions) Endotoxin: <1EU/1ug (LAL) AA Sequence: LEETLLNTKL ETADLKWVTF PQVDGQWEEL SGLDEEQHSV RTYEVCDVQR APGQAHWLRT GWVPRRGAVH VYATLRFTML ECLSLPRAGR SCKETFTVFY YESDADTATA LTPAWMENPY IKVDTVAAEH LTRKRPGAEA TGKVNVKTLR LGPLSKAGFY LAFQDQGACM ALLSLHLFYK KCAQLTVNLT RFPETVPREL VVPVAGSCVV DAVPAPGPSP SLYCREDGQW AEQPVTGCSC APGFEAAEGN TKCRACAQGT FKPLSGEGSC QPCPANSHSN TIGSAVCQCR VGYFRARTDP RGAPCTTPPS APRSVVSRLN GSSLHLEWSA PLESGGREDL TYALRCRECR PGGSCAPCGG DLTFDPGPRD LVEPWVVVRG LRPDFTYTFE VTALNGVSSL ATGPVPFEPV NVTTDREVPP AVSDIRVTRS SPSSLSLAWA VPRAPSGAVL DYEVKYHEKG AEGPSSVRFL KTSENRAELR GLKRGASYLV QVRARSEAGY GPFGQEHHSQ TQLDESEGWR EQLAVEHHHH HH Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.