Dopamine Receptor, D2L, D2LR, Rat (Control Peptide)
Catalog No : USB-D9016-33
417.25€
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| Product name | Dopamine Receptor, D2L, D2LR, Rat (Control Peptide) | ||
|---|---|---|---|
| Catalog No | USB-D9016-33 | ||
| Supplier’s Catalog No | D9016-33 | ||
| Supplier | US Biologicals | ||
| Source antigen | Rat synthetic peptide | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | |||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | Highly purified | ||
| Form | Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | Highly purified | ||
| Description | The 27 AA rat peptide was found only in the D2 long form. No significant sequence homology is seen with other dopamine receptors (D1, D2 short and D3-D5). The 27 AA rat D2RL peptide shows sequence homology of 96% with human/bovine (26/27 AA), 62% with xenopus (17/27 AA) D2L receptors. Dopamine D2 receptor is known to exist in the short (D2S) and the long (D2L)forms that are encoded by splice variants of a single gene and differ only by the presence of an additional 29 amino acid in the intracellular, cytoplasmic loop 3 (1). D2L receptor is a 446 aa, G-protein coupled, and transmembrane receptor protein (2). A 27aa Peptide (Control peptide) sequence from the rat D2 long form, within the cytoplasmic loop #3. Dopamine is an endogenous catecholamine that influences many cellular activities, including behavior, hormone synthesis and release, blood pressure and intracellular ion transport. A family of at least 5 Dopamine Receptors (DR) genes, D1-D5, have been identified based upon the amino acid identity, pharmacological specificity and effector responses. DR have been classified into either the D1-like (D1, D1B, and D5) or D2-like (D2, D3, and D4). The two isoforms of D2R, D2 long (D2L) and short D2S), are encoded by splice variants of a single gene and differ only by the presence of an additional 29aa in the intracellular domain 3 of the D2 long form. It may play a role in the coupling of the receptor to G-proteins. All members of this family have similar structure and contain 7 putative transmembrane domains. A given cell or tissue may express more than one DR. Specific radioligands do not exist that can differentiate between these DR. Therefore, specific antibodies are needed to distinguish, localize, and document changes in DR levels in cells and tissues under various normal and pathological conditions. | ||
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