Imugex

Shipping cost plus VAT not included , delivery in 7-14 business days

Categories: Peptides & Proteins / Proteins

Product name			Dopamine Receptor, D5, D5R, Rat Control Peptide
Catalog No			USB-D9019-18
Supplier’s Catalog No			D9019-18
Supplier			US Biologicals
Source antigen			Rat synthetic peptide
Reactivity			73% conserved in chicken and 64% in human D5R. No significant sequence homology exists with other dopamine receptors (D1, D2, D3 or D4). Control peptide, because of its low MW (<3kD), is not suitable for Western. It should be used for ELISA or antibody blocking experiments
Cross reactivity
Applications
Molecular weight

Storage			-20°C
Other names
Grade			Highly Purified
Purity			Highly purified
Form			Supplied as a liquid in PBS, pH 7.2
Reactivity life			12 months
Note			For reserch purpose only
Purity			Highly purified
Description			Rat D5 receptor is a 475 aa, G-protein coupled, and transmembrane receptor protein. An 18aa Peptide sequence from the rat D5 receptor within the 4th cytoplasmic domain. Dopamine is an endogenous catecholamine that influences many cellular activities, including behavior, hormone synthesis and release, blood pressure and intracellular ion transport. A family of at least 5 Dopamine Receptors (DR) genes, D1-D5, have been identified based upon the amino acid identity, pharmacological specificity and effector responses. DR have been classified into either the D1-like (D1, D1B, and D5) or D2-like (D2, D3, and D4). The two isoforms of D2R, D2 long (D2L) and short (D2S), are encoded by splice variants of a single gene and differ only by the presence of an additional 29aa in the intracellular domain 3 of the D2 long form. It may play a role in the coupling of the receptor to G-proteins. All members of this family have similar structure and contain 7 putative transmembrane domains. A given cell or tissue may express more than one DR. Specific radioligands do not exist that can differentiate between these DR. Therefore, specific antibodies are needed to distinguish, localize, and document changes in DR levels in cells and tissues under various normal and pathological conditions.