Estrogen Receptor b1, b2, Rat (ERb1, 2) Control Peptide
Catalog No : USB-E3565-17F
417.25€
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| Product name | Estrogen Receptor b1, b2, Rat (ERb1, 2) Control Peptide | ||
|---|---|---|---|
| Catalog No | USB-E3565-17F | ||
| Supplier’s Catalog No | E3565-17F | ||
| Supplier | US Biologicals | ||
| Source antigen | Rat synthetic peptide | ||
| Reactivity | Peptide shows 84% homology with the mouse ERb1 and 73% (14/19 AA) with the human ERb1 (2 | ||
| Cross reactivity | Human, | ||
| Applications | |||
| Molecular weight | |||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | Highly purified | ||
| Form | 1mg/ml soln. in PBS, pH 7.4 and 0.02% sodium merthiolate | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | Highly purified | ||
| Description | A 19aa C-terminal peptide from rat ERb. Peptide shows 84% homology with the mouse ERb1 and 73% (14/19 AA) with the human ERb1. Mouse/rat ERb1 gene encodes a protein of 485aa with a calculated size of approx. 54kD (1). Rat ERb1 is highly conserved in the DNA-binding domain (>90% homology) and the C-terminal ligand binding domain (55% homology). The A/B domain, the hinge region and the F-domain are not conserved. Rat ERb1 is primarily expressed in prostate, ovary, lung, bladder, brain, uterus, and testis. Most recently functional variants of ERb1, termed ERb2, have been cloned. ERbb has an additional 18 aa as a results of in-frame mutation within the ligand-binding domain. ERb1 is expressed in ovary, prostate, pituitary, brain, and muscle. Variants of both ERb1 and ERb2 (ERb1d3, ERb2d3) were detected that show deletion of 39 aa in the DNA-binding domain. Both ERb1 and ERb2 specifically bind to ER response element. ERa, b1 and ERb2 have been found to heterodimerize with eac | ||
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