Imugex

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Categories: Peptides & Proteins / Proteins

Product name			Estrogen Receptor b1, b2, Human (ERb1, 2) Control Peptide
Catalog No			USB-E3565-17S
Supplier’s Catalog No			E3565-17S
Supplier			US Biologicals
Source antigen			Human synthetic peptide
Reactivity
Cross reactivity			Human, Mouse, Rat
Applications
Molecular weight

Storage			-20°C
Other names
Grade			Highly Purified
Purity			Highly purified
Form			Supplied as a liquid in PBS, pH 7.4, 0.02% sodium merthiolate.
Reactivity life			12 months
Note			For reserch purpose only
Purity			Highly purified
Description			A 18aa peptide from the N-terminus of rat ERb1. Peptide is 100% identical in mouse, rat and human ERb1 (1-3). The sequence is also conserved in rat ERb2 and the variants of ERb1/b2 (ERb1d3 & ERb2d3. Mouse/rat ERb1 gene encodes a protein of 485aa with a calculated size of approx. 54kD (1). Rat ERb1 is highly conserved in the DNA-binding domain (>90% homology) and the C-terminal ligand binding domain (55% homology). The A/B domain, the hinge region and the F-domain are not conserved. Rat ERb1 is primarily expressed in prostate, ovary, lung, bladder, brain, uterus, and testis. Most recently functional variants of ERb1, termed ERb2, have been cloned. ERbb has an additional 18 aa as a results of in-frame mutation within the ligand-binding domain. ERb1 is expressed in ovary, prostate, pituitary, brain, and muscle. Variants of both ERb1 and ERb2 (ERb1d3, ERb2d3) were detected that show deletion of 39 aa in the DNA-binding domain. Both ERb1 and ERb2 specifically bind to ER response element. ERa, b1 and ERb2 have been found to heterodimerize with each other.