GABA Receptor Associated Protein, Human (GABARAP) Control Peptide
Catalog No : USB-G1015-24D
417.25€
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| Product name | GABA Receptor Associated Protein, Human (GABARAP) Control Peptide | ||
|---|---|---|---|
| Catalog No | USB-G1015-24D | ||
| Supplier’s Catalog No | G1015-24D | ||
| Supplier | US Biologicals | ||
| Source antigen | Human synthetic peptide | ||
| Reactivity | Peptide is 100% conserved in mouse and rat (2 | ||
| Cross reactivity | Mouse, Rat | ||
| Applications | |||
| Molecular weight | |||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | Highly purified | ||
| Form | Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | Highly purified | ||
| Description | A 19aa Peptide sequence near the N-terminus of human GABARAP (2) was selected for antibody production. The peptide was coupled to KLH. GABA (g-amino butyric acid) is the most abundant neurotransmitter in mammalian brain. GABA exerts its effects through ionotropic ligand-gated GABAA, GABAC and GABAB receptors (GABABRs). A family of GABA-A receptors subtypes exists, which are generated by alternative splicing of alpha 1-6, beta 1-4, gamma 1-4, delta, epsilon, pie, theta, and rho1-3 to form a heteromeric (pentameric) protein complexes. Various GABA-A subunits show distinct patterns of temporal and spatial expression that may imply its tissue specific physiological role (1). GABA A (GAA) receptor proteins (450-627 aa) are characterized by the presence of a large cytoplasmic domain that may be involved in anchoring the receptor to the cytoskeleton. Most recently, a new cellular protein, termed GABA A receptor associated protein (GABARAP), has bee shown to interact with gamma 2 subunit of GAA. GABARAP has similarity with light chain-3 microtubule associated protein 1A and 1B. N-terminus of GABARAP also possess a tubulin-binding motif. Therefore, a possible interaction of GAA, GABARAP, and tubulin suggest for the targeting and clustering of GAA. GABARAP is found in brain and most other tissues. | ||
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