Histamine Receptor 4, Human (H4R) Control Peptide
Catalog No : USB-H5090-30A
417.25€
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| Product name | Histamine Receptor 4, Human (H4R) Control Peptide | ||
|---|---|---|---|
| Catalog No | USB-H5090-30A | ||
| Supplier’s Catalog No | H5090-30A | ||
| Supplier | US Biologicals | ||
| Source antigen | Human synthetic peptide | ||
| Reactivity | The human peptide sequence is unique to human H4R | ||
| Cross reactivity | Human, | ||
| Applications | |||
| Molecular weight | |||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | Highly purified | ||
| Form | Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | Highly purified | ||
| Description | A 17 aa peptide within the cytoplasmic, C-terminus of human H4R . Histamine, one of the most important mediators of allergy and inflammation, is a chemical messenger and aminergic neurotransmitters. It plays an important role in a multitude of physiological processes in central and peripheral tissues. Histamine is synthesized in a restricted population of neurons located in the tuberomammillary nucleus of the posterior hypothalamus implicated in many brain functions (e.g. sleep/wakefulness, hormonal secretion, cardiovascular control, thermoregulation, food intake, and memory formation). In peripheral tissues histamine is stored in mast cells, basophils, enterochromaffin cells. Histamine release leads to various well-known symptoms of allergic conditions in the skin and the airway system. Histamine effects are mediated by four pharmacologically distinct receptors, the H1R, H2R , H3R and H4R receptors, which are all members of the G-protein coupled receptor (GPCR) family. Histamine receptors display 7 TM domains, an extracellular N-terminus, and a cytoplasmic C-terminus of variable length. Most recently, a novel orphan G-protein coupled receptor, named H4R (GPRv53, human 390 aa) has been cloned and characterized. It is most closely related to H3R (~37% homology). Unlike H3R, H4R has a distinct tissue distribution and it is localized in the peripheral blood leukocytes, spleen, thymus and colon. Mammalian cells expressing H4R were demonstrated to bind and respond to histamine in a concentration-dependent manner. In functional assays, an H3 receptor agonist, R-(a)-methylhistamine, but also a H3 receptor antagonist, clobenpropit, and a neuroleptic, clozapine, activated H4R-expressing cells. | ||
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