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Categories: Peptides & Proteins / Proteins

Product name			Melanocortin Receptor 4, Rat (MC4-R, G-Protein-family Coupled Receptor Transmembrane Protein) (Control Peptide)
Catalog No			USB-M2868-35
Supplier’s Catalog No			M2868-35
Supplier			US Biologicals
Source antigen			Rat synthetic peptide
Reactivity			88% (16/18 aa) homologous with human MC4-R. No significant sequence homology of mCR41 is seen with other melanocortin receptors
Cross reactivity
Applications
Molecular weight

Storage			-20°C
Other names
Grade			Highly Purified
Purity			Highly purified
Form			1mg/ml soln. in PBS, pH 7.4 and 0.02% sodium azide/Merthiolate
Reactivity life			12 months
Note			For reserch purpose only
Purity			Highly purified
Description			Melanocortins are regulatory peptides formed by post-translational processing of pro-opiomelanocortin. Melanocortin peptides have been suggested to perform a variety of physiological roles ranging from control of behavior, memory, neurotrophic properties, antipyretic and modulation of immune system, etc. Their binding sites have been found distributed in tissues ranging from lachrymal and submandibular glands, pancreas, adipose tissue, bladder, duodenum, spleen, brain, gonadal tissues and malignant melanoma tumors. Five melanocortin receptors have been characterized to date. These include melanocyte-stimulating hormone receptor (MSH or MC1-R), corticoaderenal-specific ACTH receptor (MC2-R), melacortin-3 (MC3-R), melanocortin-4 (MC4-R) and melanocortin-5 receptor (MC5-R). MC3-R and MC4-R are distributed in brain whereas MC5-R has a broad distribution. Rat Melanocortin receptor (MC4-R) is a 332 amino acid transmembrane protein belonging to the family of G-Protein coupled receptors. It is a receptor for MSH (a,b,g) and ACTH. It is found in brain, placenta, and gut tissues. Anti-Rat MC4-R antibodies were raised against 18 aa peptide mapping near the N-terminal, 1st extracellular domain of rat MC4-R.