Neurotensin Receptor 3, Control Peptide, Human (NTR3, Sortilin)
Catalog No : USB-N2177-50
417.25€
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| Product name | Neurotensin Receptor 3, Control Peptide, Human (NTR3, Sortilin) | ||
|---|---|---|---|
| Catalog No | USB-N2177-50 | ||
| Supplier’s Catalog No | N2177-50 | ||
| Supplier | US Biologicals | ||
| Source antigen | Human synthetic peptide | ||
| Reactivity | The human sequence is 94% conserved in mouse and rat NTR3 | ||
| Cross reactivity | Human, Mouse, Rat | ||
| Applications | |||
| Molecular weight | |||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | Highly purified | ||
| Form | Supplied as a liquid in PBS, pH 7.2 | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | Highly purified | ||
| Description | Control Peptide for N2177-51 (antiserum) and N2177-51 (affinity purified) An 18 aa peptide sequence close to the extracellular, N-terminus region of human NTR3 . Neurotensin (NT) is an endogenous tridecapeptide neurotransmitter that influences distinct central and peripheral physiological functions in mammals. Central administration of NT modulates dopaminergic transmission and triggers hypothermic and naloxone-insensitive analgesic responses, whereas peripheral effects include hypotension, decrease gastric acid release, potentiation of lipid digestion. NT is widely distributed throughout the CNS. It has been localized to catecholamine-containing neurons. NT initiates its biological action by interacting with two distinct G-protein coupled receptors (NTR1 and NTR2). Recently, a third receptor NTR3 has been identified that is identical to gp95/sortilin and it is not coupled via the G-proteins. All three receptors bind NT through its C-terminal hexapeptide sequence (8 RRPYIL 13). Biologically active NT (NT8-13) has also been shown to interact with the extracellular domain 3 (between TM6-7) of NTR1. Most recently, a novel, non-GPCR, NTR3/sortilin/gp95/NT3 (mouse 825 aa, rat 748 aa; human 833 aa, chromosome 1p21.3; ~92% identity between human and mouse) also binds NT. Sortilin was initially isolated as by its affinity for receptor-associated protein (RAP). NTR3, the first non-GPCR neuropeptides receptor, sequence includes a putative secretory signal peptide, a furin cleavage site, and a single transmembrane domain near the C-terminus. The mature protein has 44 N-terminal residues removed during processing. It is homologous to the yeast protein Vps10p and the human sortilin-related receptor. The C terminus of the protein contains a lysosomal sorting motif shared by the mannose-6-phosphate receptors. NTR3 is expressed at high levels in brain, spinal cord, heart, skeletal muscle, thyroid, placenta, and testis. | ||
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