Imugex

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Categories: Peptides & Proteins / Proteins

Product name			mGluR5,1a peptide(Metabotropic Glutamate Receptor)
Catalog No			USB-M3884-79C
Supplier’s Catalog No			M3884-79C
Supplier			US Biologicals
Source antigen
Reactivity
Cross reactivity
Applications
Molecular weight

Storage			-20°C
Other names
Grade			Purified
Purity			Purified
Form			Supplied as a lyophilized powder.
Reactivity life			12 months
Note			For reserch purpose only
Purity			Purified
Description			Sequence (linear): C-Terminal 13 amino acids LIIRDYTQSSSSL of rat mGluR5, Metabotropic Glutamate Receptor 5. Corresponding antibody M3884-79B shows reactivity to mGluR1a with a species reactivity to human, rat, mouse and feline. Metabotropic glutamate receptors have been classified into three groups. In general, class I receptors (mGluR1 and mGluR5) mediate the excitation of neurons, whereas activation of class II (mGluR2 and mGluR3) and class III (mGluR4a, mGluR7a, mGluR7b and mGluR8) results in a depression of synaptic transmission. Class I mGluRs are localized in the postsynaptic membrane and are positively coupled to phospholipase C (PLC). Class II and class III mGluRs localized to the presynaptic membrane and are negatively coupled to adenylate cyclase. It has been speculated that mGluR2 and/or mGluR3 may play a role in the modulation of the mossy terminal function. Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Stable for 12 months at -20°C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.