FCRLB, Recombinant, Human (FCRL2, FCRY, FREB2, Fc Receptor-like B, Fc Receptor homolog expressed in B cells Protein 2, Fc Receptor-like and Mucin-like Protein 2, Fc Receptor-like Protein 2, Fc Receptor-related Protein Y, FCRLM2, FCRLY, FcRY, FLJ31052, FREB-2, RP11-474I16.6)
Catalog No : USB-F0025-73
705.77€
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| Product name | FCRLB, Recombinant, Human (FCRL2, FCRY, FREB2, Fc Receptor-like B, Fc Receptor homolog expressed in B cells Protein 2, Fc Receptor-like and Mucin-like Protein 2, Fc Receptor-like Protein 2, Fc Receptor-related Protein Y, FCRLM2, FCRLY, FcRY, FLJ31052, FREB-2, RP11-474I16.6) | ||
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| Catalog No | USB-F0025-73 | ||
| Supplier’s Catalog No | F0025-73 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, Murine myeloma cell line | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 6570 | ||
| Storage | 4°C/-20°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ≥90% (SDS-PAGE) | ||
| Form | Supplied as a lyophilized powder from PBS, EDTA. Carrier free. Reconstitute with 100ug/ml PBS. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ≥90% (SDS-PAGE) | ||
| Description | FCRLB, also known as FCRL2, FCRY, and FREB2, is a 60kD protein with sequence homology to classical Fc receptors. There are at least six type 1 transmembrane FCRL proteins and two that lack transmembrane segments. Each family member contains between three and nine immunoglobulin-like domains. FCRL proteins are differentially expressed within the B cell lineage and can either promote or inhibit B cell proliferation and activation. According to our testing, FCRLB binds to purified human IgG with high affinity. Human FCRLB shares 82% and 85% aa sequence identity with mouse and rat FCRLB, respectively. It contains a putative signal peptide, three immunoglobulin-like domains, and a mucin-like stalk that is rich in Pro, Ser, and Thr residues. The stalk region also contains di-Leu motifs and an unpaired cysteine. Alternative splicing generates isoforms with deletions in the putative signal peptide and substitutions and/or truncations in the third Ig -like domain. When expressed in transfectants, FCRLB is not secreted but shows a diffuse intracellular localization. FCRLB is expressed at a low level in placenta and in B lineage cells of the germinal center. It is upregulated in B cells by BAFF and LPS. Among non-hematopoietic cells, FCRLB is expressed in fibroblasts, melanocytes, and melanoma. It is preferentially expressed in nonproliferating cells and at the onset of apoptosis. Source: Murine myeloma cell line, NS0-derived. Ala18-Ser426, with a C-terminal 6x-His tag. Molecular Weight: 65-70kD (SDA-PAGE, reducing conditions) Biological Activity: Measured by the ability to bind human IgG with an estimated KD <120nM. Endotoxin: ≤1EU/ug (LAL) Storage and Stability: Lyophilized powder may be stored at -20°C. Reconstitute with 100ug/ml PBS. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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