KIR2DS4, Fc Chimera, Recombinant, Human (Killer Cell Immunoglobulin-Like Receptor 2DS4, CD158 Antigen-like Family Member I, MHC Class I NK Cell Receptor, Natural Killer-associated Transcript 8, NKAT-8, P58 Natural Killer Cell Receptor Clones CL-39/CL-17, p58 NK Receptor CL-39/CL-17, CD158i, KKA3, NKAT8)
Catalog No : USB-K1858-60A
705.77€
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| Product name | KIR2DS4, Fc Chimera, Recombinant, Human (Killer Cell Immunoglobulin-Like Receptor 2DS4, CD158 Antigen-like Family Member I, MHC Class I NK Cell Receptor, Natural Killer-associated Transcript 8, NKAT-8, P58 Natural Killer Cell Receptor Clones CL-39/CL-17, p58 NK Receptor CL-39/CL-17, CD158i, KKA3, NKAT8) | ||
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| Catalog No | USB-K1858-60A | ||
| Supplier’s Catalog No | K1858-60A | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, NSO cells | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 51.2 | ||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~95% (SDS-PAGE) | ||
| Form | Supplied as a lyophilized powder in PBS. BSA free. Reconstitute with PBS to 0.1mg/ml. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95% (SDS-PAGE) | ||
| Description | KIR2DS4 (2DS4), previously called NKAT-8 and designated CD158i, is a type I transmembrane glycoprotein that belongs to the killer cell Ig-like receptor (KIR) family. KIRs are expressed on CD56dim NK cells and T cell subsets where they differentiate normal from abnormal cells and regulate effector functions in the innate immune system. KIRs are named for the number of Ig-like domains (2D or 3D) in the extracellular domain (ECD), and whether they have long or short (L, S) cytoplasmic tails. KIR2DS4 cDNA encodes 304aa including a 21aa signal sequence, a 224aa ECD, a 20aa transmembrane sequence and a 39aa cytoplasmic domain. KIR receptors have no structural orthologs in nonprimates, although mouse 49aa proteins perform similar functions. Like other activating KIRs, KIR2DS4 has a short tail and a positively charged aa within the transmembrane domain that interacts with the ITAM-bearing signaling adaptor, DAP12. Expression of activating KIR is balanced with inhibitory KIR to impart specificity to the immune response. KIR2DS4 recognizes six HLA-C allotypes and two HLA-A allotypes (A*1101 and A*1102) but no HLA-B allotypes. It has also been suggested that KIR2DS4 recognizes a non-MHC ligand, based on specific binding to melanoma cells that lack MHC Class I. A common allele, KIR2DS4*003, is present in up to 89% of Caucasians and ~30% of Asians; it creates a prematurely terminated, soluble, inactive form. Lack of functional KIR2DS4 can potentially create unbalanced inhibition of killer cell function. Source: Recombinant corresponding to aa22-245 from human KIR2DS4 expressed in mouse Murine myeloma cell line, NS0. Molecular Weight: ~51.2kD Biological Activity: Measured by its ability to bind BJAB human Burkitt's lymphoma cells in a flow cytometry assay. Endotoxin: ~1EU/1ug (LAL) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 3 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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