TRKC, Active, Recombinant, Human, GST-Tag (NT-3 Growth Factor Receptor, GP145-TrkC, Trk-C, Neurotrophic Tyrosine Kinase Receptor Type 3, TrkC Tyrosine Kinase, NTRK3)
Catalog No : USB-137386
627.60€
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| Product name | TRKC, Active, Recombinant, Human, GST-Tag (NT-3 Growth Factor Receptor, GP145-TrkC, Trk-C, Neurotrophic Tyrosine Kinase Receptor Type 3, TrkC Tyrosine Kinase, NTRK3) | ||
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| Catalog No | USB-137386 | ||
| Supplier’s Catalog No | 137386 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, Sf9 insect cells | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 68 | ||
| Storage | -70°C | ||
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| Other names | |||
| Grade | Purified | ||
| Purity | Purified (~50%) | ||
| Form | Supplied as a liquid in 45mM Tris-HCl, pH 8.0, 124mM sodium chloride, 2.4mM potassium chloride, 3mM DTT, 10% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | Purified (~50%) | ||
| Description | TRKC, a member of the insulin receptor subfamily of Tyr protein kinases, is a receptor for neurotrophin-3 (NT-3). Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats. Source: Recombinant corresponding to aa456-825 from human TRKC, fused to GST-tag at N-terminal, expressed in Sf9 cells via a baculovirus expression system. Molecular Weight: ~68kD Applications: Suitable for use in the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Specific Activity: ~1pmol/min/ug Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | ||
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