RAGE, Recombinant, Human, His-Tag (Receptor for Advanced Glycosylation End Products, Advanced Glycosylation End Product-specific Receptor, AGER)
Catalog No : USB-169732
387.37€
0.00€
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| Product name | RAGE, Recombinant, Human, His-Tag (Receptor for Advanced Glycosylation End Products, Advanced Glycosylation End Product-specific Receptor, AGER) | ||
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| Catalog No | USB-169732 | ||
| Supplier’s Catalog No | 169732 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, Human cells | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 35 | ||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~95% (SDS-PAGE, HPLC) | ||
| Form | Supplied as a lyophilized powder from 20mM PBS, 150mM sodium chloride, pH 7.2. Reconstitute with sterile PBS to 0.1mg/ml. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95% (SDS-PAGE, HPLC) | ||
| Description | Advanced glycosylation end product-specific receptor, also known as receptor for advanced glycosylation end products, AGER and RAGE, belongs to the immunoglobulin superfamily of cell surface molecules. It lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Besides AGEs, AGER is also able to bind other ligands which is thought to result in pro-inflammatory gene activation. It is known that AGER serves as a mediator of both acute and chronic vascular inflammation in certain conditions such as atherosclerosis and in particular as a complication of diabetes. Furthermore, it plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Source: Recombinant protein corresponding to aa23-344 from human RAGE fused with a poly-histidine tag at the C-terminus, expressed in human cells. Molecular Weight: ~35kD Endotoxin: <0.1ng/ug Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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