Imugex

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Categories: Peptides & Proteins / Proteins

Product name			EGFR, Recombinant, Human, 629aa (Proto-oncogene c-ErbB-1, Receptor Tyrosine-protein Kinase erbB-1, ERBB, ERBB1, HER1)
Catalog No			USB-207161
Supplier’s Catalog No			207161
Supplier			US Biologicals
Source antigen			Recombinant, Sf9 cells
Reactivity
Cross reactivity
Applications
Molecular weight			85

Storage			-20°C
Other names
Grade			Highly Purified
Purity			~90% (SDS-PAGE)
Form			Supplied as a lyophilized powder. Soluble in H2O and most aqueous buffers. Reconstitute with PBS to ~50ug/ml.
Reactivity life			12 months
Note			For reserch purpose only
Purity			~90% (SDS-PAGE)
Description			EGFR has been shown to bind a subset of the EGF family ligands, including EGF, amphiregulin, TGF-alpha, betacellulin, epiregulin, heparin-binding EGF and neuregulin-2 in the absence of a co-receptor. Ligand binding induces EGFR homodimerization as well as heterodimerization with ErbB2, resulting in kinase activation, tyrosine phosphorylation and cell signaling. EGFR signaling has been shown to regulate multiple biological functions including cell proliferation, differentiation, motility and apoptosis. In addition, EGFR signaling has also been shown to play a role in carcinogenesis. Source: Recombinant protein corresponding to 629aa from human EGFR, fused to Strep-tag at C-terminal, expressed in Sf9 cells. Molecular Weight: ~85kD Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.