Nerve Growth Factor Receptor, Fc Chimera, Human (Low-affinity Nerve Growth Factor Receptor, NGF Receptor, Gp80-LNGFR, p75 ICD, Low Affinity Neurotrophin Receptor p75NTR, p75NTR, CD271)
Catalog No : USB-215380
532.20€
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| Product name | Nerve Growth Factor Receptor, Fc Chimera, Human (Low-affinity Nerve Growth Factor Receptor, NGF Receptor, Gp80-LNGFR, p75 ICD, Low Affinity Neurotrophin Receptor p75NTR, p75NTR, CD271) | ||
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| Catalog No | USB-215380 | ||
| Supplier’s Catalog No | 215380 | ||
| Supplier | US Biologicals | ||
| Source antigen | Human 293 cells | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 7510050.8 | ||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~95% (SDS-PAGE) | ||
| Form | Supplied as a lyophilized powder. Reconstitute with 500ul PBS. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95% (SDS-PAGE) | ||
| Description | Nerve growth factor (NGF) receptor, also known as p75NTR, is a low affinity NGF receptor. It binds with equal affinity neurotrophins such as beta NGF, BDNF, NT-3 and NT-4. NGF receptors mediate signaling of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. These receptors are also thought to play a role in neurogenerative diseases such as Alzheimers disease. The NGF receptor is a type I transmembrane glycoprotein (399aa) consisting of a signal peptide (28aa), an extracellular domain (222aa) which contains four cysteine rich domains responsible for ligand binding, a transmembrane domain (22aa) and a cytoplasmic domain (155aa). Source: Nerve Growth Factor Receptor-Fc Chimera, from human DNA sequence encoding the signal peptide and extracellular domain of human NGF receptor aa1-250 was fused to the Fc region of human IgG1 aa93-330. The chimeric protein was expressed in modified human 293 cells. Molecular Weight: ~75kD-100kD with post-translational modification and ~50.8kD unmodified. Biological Activity: The ED50 of the NGF Receptor-Fc chimera is typically 0.7-1ug/ml as measured by its ability to neutralize beta NGF mediated proliferation of the human growth- factor dependent TF-1 cell line. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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