Prolactin Receptor, Recombinant, Rat (PRL-R, Lactogen Receptor, Prlr, PRL, Luteotropic Hormone, LTH, PRLR, PRL R)

Catalog No : USB-220197
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Product name Prolactin Receptor, Recombinant, Rat (PRL-R, Lactogen Receptor, Prlr, PRL, Luteotropic Hormone, LTH, PRLR, PRL R)
Catalog No USB-220197
Supplier’s Catalog No 220197
Supplier US Biologicals
Source antigen Recombinant, E. coli
Reactivity
Cross reactivity
Applications
Molecular weight 24.12
Storage -20°C
Other names
Grade Highly Purified
Purity ~97% (SDS-PAGE, HPLC)
Form Supplied as a lyophilized powder in 0.0045mM NaHCO3. No preservative added. Reconstitute with sterile ddH2O to 0.1-1mg/ml.
Reactivity life 12 months
Note For reserch purpose only
Purity ~97% (SDS-PAGE, HPLC)
Description Prolactin is a pituitary hormone that plays a role in the stimulation of milk production, salt and H2O regulation, growth, development and reproduction. The primary step in its action is the binding to a specific membrane receptor (prolactin receptor) which belongs to the superfamily of class 1 cytokine receptors. Prolactin is a hormone involved in a range of significant functions including ion transport and osmoregulation, stimulation of milk, protein synthesis as well as the regulation of numerous reproductive functions. Prolactin exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane Prolactin receptor. PRLR varies in size (short and long forms) with tissue source and species, from ~40kD-100kD. Source: Recombinant protein corresponding to 206aa from the extracellular domain of rat Prolactin Receptor, expressed in E. coli. Molecular Weight: ~24.12kD Biological Activity: Determined by the dose-dependent inhibition of Prolactin stimulated proliferation of Nb2 cells and by high affinity binding of ovine Prolactin and other lactogenic hormones. Endotoxin: <0.1ng/ug Storage and Stability: Lyophilized powder may be stored at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.