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Categories: Peptides & Proteins / Proteins

Product name			CHRNA3, Recombinant, Human, aa32-240, His-Tag (Neuronal acetylcholine receptor subunit alpha-3 isoform)
Catalog No			USB-349787
Supplier’s Catalog No			349787
Supplier			US Biologicals
Source antigen			Recombinant, E. coli
Reactivity
Cross reactivity
Applications
Molecular weight			27

Storage			-20°C
Other names
Grade			Purified
Purity			~80% (SDS-PAGE)
Form			Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 10% glycerol.
Reactivity life			6 months
Note			For reserch purpose only
Purity			~80% (SDS-PAGE)
Description			CHRNA3 also known as neuronal acetylcholine receptor subunit alpha-3 isoform 1 is a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. CHRNA3 is a ligand-gated ion channel that likely plays a role in neurotransmission. CHRNA3 have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. Source: Recombinant protein corresponding to aa32-240 of human CHRNA3, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~27kD AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSSEAEHRL FERLFEDYNE IIRPVANVSD PVIIHFEVSM SQLVKVDEVN QIMETNLWLK QIWNDYKLKW NPSDYGGAEF MRVPAQKIWK PDIVLYNNAV GDFQVDDKTK ALLKYTGEVT WIPPAIFKSS CKIDVTYFPF DYQNCTMKFG SWSYDKAKID LVLIGSSMNL KDYWESGEWA IIKAPGYKHD IKYNCCEEIY PDITYSLYIR RL Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.