OSCAR, Recombinant, Human, aa19-282, His-Tag (OSCAR, PIgR-3, PIGR3, Osteoclast-Associated Immunoglobulin-Like Receptor Isoform)
Catalog No : USB-470248
564.38€
0.00€
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| Product name | OSCAR, Recombinant, Human, aa19-282, His-Tag (OSCAR, PIgR-3, PIGR3, Osteoclast-Associated Immunoglobulin-Like Receptor Isoform) | ||
|---|---|---|---|
| Catalog No | USB-470248 | ||
| Supplier’s Catalog No | 470248 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, Insect Cell | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 29.24057 | ||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~90% (SDS-PAGE) | ||
| Form | Supplied as a liquid in PBS, pH 7.4, 10% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~90% (SDS-PAGE) | ||
| Description | OSCAR, also known as osteoclast-associated immunoglobulin-like receptor isoform 6, is an activating receptor expressed by human myeloid cells. It is a receptor for surfactant protein D that activates TNF-Alpha release from human CCR2+ inflammatory monocytes. It is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells. Its expression is detected specifically in preosteoclasts or mature osteoclasts. It is upregulated on monocytes from rheumatoid arthritis (RA) patients with active disease, and these monocytes show an increased proosteoclastogenic potential. Source: Recombinant protein corresponding to aa19-282 from human OSCAR, fused to His-Tag at C-terminal, expressed in Insect Cell. Molecular Weight: ~29.2kD (270aa) ~40-57kD (SDS-PAGE under reducing conditions) AA Sequence: DITPSVPPAS YHPKPWLGAQ PATVVTPGVN VTLRCRAPQP AWRFGLFKPG EIAPLLFRDV SSELAEFFLE EVTPAQGGSY RCCYRRPDWG PGVWSQPSDV LELLVTEELP RPSLVALPGP VVGPGANVSL RCAGRLRNMS FVLYREGVAA PLQYRHSAQP WADFTLLGAR APGTYSCYYH TPSAPYVLSQ RSEVLVISWE GEGPEARPAS SAPGMQAPGP PPSDPGAQAP SLSSFRPRGL VLQPLLPQTQ DSWDPAPPPS DPGVHHHHHH Endotoxin: <1EU/1ug (LAL) Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | ||
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