TIE1, Human, Control Peptide (TIE-1, Tyrosine Protein Kinase Receptor, Tunica Internal Endothelial Cell Kinase)
Catalog No : USB-T5498-65E
417.25€
0.00€
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| Product name | TIE1, Human, Control Peptide (TIE-1, Tyrosine Protein Kinase Receptor, Tunica Internal Endothelial Cell Kinase) | ||
|---|---|---|---|
| Catalog No | USB-T5498-65E | ||
| Supplier’s Catalog No | T5498-65E | ||
| Supplier | US Biologicals | ||
| Source antigen | Human synthetic peptide | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | |||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Purified | ||
| Purity | Purified | ||
| Form | Supplied as a lyophilized powder from PBS, 0.05% sodium azide. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | Purified | ||
| Description | Embryonic vascular system undergoes a series of complex, highly regulated series of events involving differentiation, migration and association of primitive endothelial cells. This process is termed vasculogenesis. A further remodeling of the primitive vascular system forms the mature cardiovascular system. This process is known as angiogenesis (sprouting of new capillary vessels from pre-existing vasculature). A family of receptor tyrosine kinases TIE1 and TIE 2 or Tek has been identified in vascular endothelium and hematopoietic cells. Mice lacking TIE 1 or TIE 2 are lethal. Ties may represent the earliest endothelial cell lineage marker and may regulate the endothelial cell proliferation, differentiation, and proper patterning during vasculogenesis. TIEs appear to be acting downstream of the VEGFRs. Tie-1 (human 1138 AA; mouse 1134 aa) is a type 1 membrane receptor protein specifically expressed in developing vascular endothelial cells. Tie-1 extracellular portion (25-279 aa) contains 3 fibronectin type III-like and 2 Ig-like C2-type, and 3-EGF-like domains. Applications: Suitable for use in ELISA as a control peptide for T5498-65C & T5498-65F. Other applications not tested. Recommended Dilution: ELISA: Use 50-100 ng of control peptide/well Optimal dilutions to be determined by the researcher. Species Sequence Homology: Mouse-90%; Bovine-63%. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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