TIE-1, Fc Chimera, Recombinant, Human (Tyrosine Kinase With Ig And EGF Homology Domains 1)
Catalog No : USB-299542
419.55€
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| Product name | TIE-1, Fc Chimera, Recombinant, Human (Tyrosine Kinase With Ig And EGF Homology Domains 1) | ||
|---|---|---|---|
| Catalog No | USB-299542 | ||
| Supplier’s Catalog No | 299542 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, Insect Cells | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 250 | ||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~90% (RP-HPLC, SDS-PAGE) | ||
| Form | Supplied as a lyophilized powder in 20mM Tris, 0.5M sodium chloride, 10% sucrose. Reconstitute with 100ug/ml sterile ddH2O. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ~90% (RP-HPLC, SDS-PAGE) | ||
| Description | TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1124aa residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Whereas two ligands have been described for TIE-2 [angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2)], so far no ligand was found for TIE-1. Source: Recombinant protein corresponding to human TIE-1, a homodimeric, glycosylated, polypeptide containing 749aa, fused with the Fc part of human IgG1, expressed in Insect Cells. Molecular Weight: ~250kD Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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