Resistin-like Molecule, alpha, Mouse, Control Peptide (RELMa)
Catalog No : USB-R1587-03
417.25€
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| Product name | Resistin-like Molecule, alpha, Mouse, Control Peptide (RELMa) | ||
|---|---|---|---|
| Catalog No | USB-R1587-03 | ||
| Supplier’s Catalog No | R1587-03 | ||
| Supplier | US Biologicals | ||
| Source antigen | Mouse synthetic peptide | ||
| Reactivity | Sequence is only 50% conserved in rat and no appreciable homology with human RELM-alpha | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | |||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | Highly purified | ||
| Form | Supplied as a liquid in PBS, pH 7.2 | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | Highly purified | ||
| Description | Control Peptide for R1587-01 (antiserum) and R1587-04 (affinity purified) A 14-aa peptide sequence near the N-terminus of mouse RELM-alpha (1) was coupled with KLH. Resistance to insulin characterizes type 2 diabetes, the most common form of diabetes. There is a strong link between type 2 diabetes and obesity, as most patients tend to be obese. Thiozolidinediones (TZDs), a new class of anti-diabetic drugs, enhances target-tissue sensitivity to insulin. A screen of genes down regulated by TZD in adipocyte led to the discovery of a new protein hormone called resistin (for resistance to insulin). Resistin, specifically produced and secreted by adipocyte, is present at elevated levels in the blood of obese animals, and is down regulated by fasting and anti-diabetic drugs. Antibody to resistin stimulated glucose uptake and improved insulin sensitivity in obese mice. Some other protein related to resistin has been called resistin-related molecules (RELM-alpha and beta). Resistin family of proteins was also identified as proteins (FIZZ1-3, for Found in Inflammatory zone) involved in allergy and inflammation. RELM-alpha/FIZZ1/PMNG1 (Parasite-induced Macrophage Novel Gene 1 (prepeptides: mouse/rat 111 aa; ~77% identity) is 63% related to resistin at the C-terminus (38 aa). The N-terminus of RELM-alpha is less conserved at the N-terminus. RELM-alpha mRNA was most abundant in white adipose tissue. It is also expressed in mammary tissue with significant fat pads. Unlike resistin, RELM-alpha is not expressed in 3T3-L1 adipocyte or in preadipocytes. It is also found in heart, lung and tongue, where resistin is absent. In mice, RELM-alpha/FIZZ1 is found at low levels in a subset of bronchial epithelial cells and in non-neuronal cells adjacent neurovascular bundles in the peribronchial stroma, and in the wall of the large and small bowel. FIZZ1 expression is induced hypertrophic, hyperplastic bronchial epithelium. | ||
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