Imugex

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Categories: Peptides & Proteins / Proteins

Product name			RIZ1, Recombinant, Human, aa2-200, GST-tag (KMT8, PRDM2, PR Domain Zinc Finger Protein 2, Retinoblastoma Protein-interacting Zinc Finger Protein)
Catalog No			USB-220232
Supplier’s Catalog No			220232
Supplier			US Biologicals
Source antigen			Recombinant, E. coli
Reactivity
Cross reactivity
Applications
Molecular weight			49.5

Storage			-70°C
Other names
Grade			Highly Purified
Purity			~95% (SDS-PAGE)
Form			Supplied as a liquid in 50mM Tris, pH 7.5, 150mM sodium chloride, 20% glycerol.
Reactivity life			12 months
Note			For reserch purpose only
Purity			~95% (SDS-PAGE)
Description			Retinoblastoma protein-interacting zinc finger protein 1 (RIZ1), also known as PRDM2, is a SAM-dependent histone methyltransferase that specifically methylates histone H3 on lysine 9. RIZ1 contains 8 zinc-finger motifs and 1 PR domain. The RIZ gene encodes two different proteins, RIZ1 and RIZ2. RIZ1 is a tumor suppressor that can arrest the cell cycle and induce apoptosis. RIZ2 however, is a proto-oncoprotein lacking the N-terminal PR domain containing the methyltransferase activity. When RIZ1 is silenced or mutated, the reduced methyltransferase activity can lead to inheritable changes in chromatin methylation and gene expression patterns. Source: Recombinant protein corresponding to aa2-200 from human RIZ1, fused to GST-tag at N-terminal, expressed in E. coli. Molecular Weight: ~49.5kD (aa2-200 + NT GST Tag) Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.