Imugex

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Categories: Peptides & Proteins / Proteins

Product name			Ribosomal Protein S6, phosphorylated (Ser235), Immunizing Peptide
Catalog No			USB-R2031-35
Supplier’s Catalog No			R2031-35
Supplier			US Biologicals
Source antigen
Reactivity
Cross reactivity
Applications
Molecular weight			1668

Storage			-20°C
Other names
Grade			Purified
Purity			Purified
Form			Supplied as a lyophilized powder.
Reactivity life			12 months
Note			For reserch purpose only
Purity			Purified
Description			Synthetic peptide corresponding to amino acids 229–242 (AKRRRL [pS]SLRASTS) (linear) of human ribosomal protein S6. To effectively promote growth and cell division in a sustained manner, growth factors and mitogens must upregulate translation. Growth factors and mitogens induce the activation of p70 S6 kinase, which in turn phosphorylate the S6 ribosomal protein. Phosphorylation of S6 correlates with an increase in translation, particularly of mRNAs with an oligopyrimidine tract in their 5' untranslated regions. This group of mRNAs (5'TOP) encodes proteins involved in cell cycle progression and proteins that are part of the translational machinery, such as ribosomal proteins and elongation factors. The main in vivo S6 ribosomal protein phosphorylation sites, including Ser235, Ser236, Ser240 and Ser244, have been identified and are located within a small 19 amino acid region at its carboxyl terminus. Molecular Weight: 1668D Quantity: As reported Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Stable for 12 months at -20°C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.