Ribosomal Protein P0, Recombinant, Human (RPP0)
Catalog No : USB-R2031-28R
377.02€
0.00€
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| Product name | Ribosomal Protein P0, Recombinant, Human (RPP0) | ||
|---|---|---|---|
| Catalog No | USB-R2031-28R | ||
| Supplier’s Catalog No | R2031-28R | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, Sf9 insect cells | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 35.1 | ||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Purified | ||
| Purity | ≥ 80% (SDS-PAGE) | ||
| Form | Supplied as a liquid in 20mM HEPES buffer, pH 7.5, 0.01mM EDTA. 0.02% SDS. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ≥ 80% (SDS-PAGE) | ||
| Description | The ribosomal phosphoproteins(P protein antigens) are associated with the large ribosomal subunit and therefore are antigenic targets with a cytoplasmic localization. Three P proteins have been described: P0 with a molecular weight of 35kD, P1 (19 kD) and P2 (17 kD). Autoantibodies against ribosomal P proteins are present in 10 % of SLE patients. If anti-ribosomal P antibodies were to occur in the absence of other typical SLE associated autoantibodies, they may account for some patients with so-called ANA-negative lupus. It has been reported that lupus patients positive for anti-ribosomal P autoantibodies have a high frequency of CNS involvement, suggesting a marker use for these antibodies. Description: Recombinant Human Ribosomal Phosphoprotein P0 produced in SF9 is a glycosylated, polypeptide chain having a molecular mass of 35,096 dalton. Recombinant Human Ribosomal Phosphoprotein P0 is expressed with a -6xHis tag and purified by proprietary chromatographic techniques. Immunological Functions: 1. Binds IgG-type human auto-antibodies. 2. Standard ELISA test (checker-board analysis of positive/negative sera panels. Applications: Western-Blot with monoclonal anti-hexa-His-tag antibody & SLE sera (Systemic Lupus Erythematodes Disease). Coating Concentration: 0.3-0.7ug/ml (depending on the type of ELISA plate and coating buffer). Suitable for biotinylation and iodination. Stability: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze-thaw cycles. | ||
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