SMN, Recombinant, Human, aa1472-1613, GST-tag (Gemin-1, Component of Gems 1, Survival Motor Neuron Protein)
Catalog No : USB-220273
449.44€
0.00€
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| Product name | SMN, Recombinant, Human, aa1472-1613, GST-tag (Gemin-1, Component of Gems 1, Survival Motor Neuron Protein) | ||
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| Catalog No | USB-220273 | ||
| Supplier’s Catalog No | 220273 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 42.6 | ||
| Storage | -70°C | ||
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| Other names | |||
| Grade | Purified | ||
| Purity | ~90% (SDS-PAGE) | ||
| Form | Supplied as a liquid in 50mM Tris-HCl, pH 8.0, 150mM sodium chloride, 20% glycerol. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ~90% (SDS-PAGE) | ||
| Description | Tudor domains are small protein structural motifs of ~50aa related to the “Royal family” of methyl readers, which also includes chromo, MBT, PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or with other domains and are found in many proteins that are involved in RNA metabolism, germ cell development, transposon silencing, DNA damage response, histone modification and chromatin remodeling. The tudor domains recognize symmetric methylated arginine or methylated lysine residues. The Survival of Motor Neurons (SMN) protein participates in RNA splicing. The Tudor domain of SMN recognizes and binds methylated Sm proteins, which bind small nuclear RNA. SMN is encoded in humans by two separate genes, SMN1 and SMN2, which differ by one base in exon 7. In motor neuron cells, approximately 90% of the SMN2 transcripts are spliced to exclude exon 7. The SMN2 transcripts without exon 7 are less stable than SMN1 transcripts. Consequently, defects in human SMN1 result in the death of motor neuron cells and spinal muscular atrophy, which is the leading genetic cause of infantile death. This protein product contains the tudor domain region of SMN. The sequence of this region is identical in both the SMN1 and the SMN2 genes. Source: Recombinant protein corresponding to aa1472-1613 from the tudor domain region of human SMN, fused to GST-tag at N-terminal, expressed in E. coli. Molecular Weight: ~42.6kD (aa1472-1613, NT GST-tag) Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | ||
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