SCGB1A1+3A2, Respiratory, Recombinant, Human
Catalog No : USB-471596
423.00€
0.00€
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| Product name | SCGB1A1+3A2, Respiratory, Recombinant, Human | ||
|---|---|---|---|
| Catalog No | USB-471596 | ||
| Supplier’s Catalog No | 471596 | ||
| Supplier | US Biologicals | ||
| Source antigen | E. coli, human | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 16 | ||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~95% (SDS-PAGE) | ||
| Form | Supplied as a liquid in 0.9% sodium chloride. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95% (SDS-PAGE) | ||
| Description | Uteroglobin (SCGB1A1) which belongs to the Secretoglobin (SCGBs) superfamily, is a multifunctional protein that exerts anti-inflammatory and anti-tumorigenic effects by binding small hydrophobic molecules such as phospholipids and prostaglandins. Uteroglobin is involved in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. SCGB1A1 is expressed by Clara cells, the non-ciliated, non-mucous secretory cells predominant in lung bronchioles, and by other epithelia which communicate with the external environment. On top of sequestering pro-inflammatory mediators and carcinogens, Uteroglobin is implicated in the inhibition of cell migration and invasion, platelet aggregation, and T cell differentiation. SCGB1A1 gene defects are associated with a susceptibility to asthma. Secretoglobin Family 3A Member 2 (SCGB3A2) is a secreted lung surfactant protein and a downstream target of thyroid transcription factor. A single nucleotide polymorphism in the promoter of the SCGB3A2 gene results in susceptibility to asthma. Two individually-made recombinant human secretoglobins that are highly expressed in the respiratory tract, specifically SCGB1A1 and SCGB3A2. Source: Recombinant protein corresponding to human Respiratory SCGB1A1+3A2, expressed in E. coli. Molecular Weight: ~16kD Biological Activity: ≥ 80% inhibition of sPLA2-Type 1b in standardized assay Endotoxin: < 5EU/1mg (LAL) Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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