CETP, Control Peptide (Cholesteryl Ester Transfer Protein)

Catalog No : USB-C3050A
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Product name CETP, Control Peptide (Cholesteryl Ester Transfer Protein)
Catalog No USB-C3050A
Supplier’s Catalog No C3050A
Supplier US Biologicals
Source antigen
Reactivity Immunizing peptide corresponds to the C-terminal amino acid residues 140-151 of human CETP protein, C(140)DSGRVRTDAPD(151). Corresponds to anti-CETP C3050 which detects cholesteryl ester transfer protein (CETP) from human tissues.
Cross reactivity
Applications
Molecular weight
Storage 4°C (-20°C Glycerol)
Other names
Grade Purified
Purity Purified
Form Supplied as a lyophilized powder.
Reactivity life 12 months
Note For reserch purpose only
Purity Purified
Description It has been proposed that high density lipoproteins (HDLs) function jointly with lecithin:cholesterol acyltransferase and CETP to facilitate cholesterol transport from tissues to the liver. This mechanism, referred to as reverse cholesterol transport, is physiologically important because it maintains systemic cholesterol levels. CETP is responsible for neutral lipid transfer activity in plasma in numerous species. Since CETP is able to specifically accelerate the exchange of lipid components between pro- and anti-atherogenic lipoprotein fractions, it may be a key determinant of the global atherogenicity of the plasma lipoprotein profile and arises as a possible target in atherosclerosis prevention. In general, elevated levels of CETP have been associated with increased risk of coronary heart disease. Applications: Suitable for use in ELISA, Western Blotting neutralization and control experiments. Other applications not tested. Recommended Dilution: Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions. Optimal dilutions to be determined by the researcher. Reconstitution: Reconstitute with 0.1ml of distilled water. Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.