Imugex

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Categories: Peptides & Proteins / Proteins

Product name			SIRT4, Recombinant, Human, GST-tag (SIR2-like Protein 4, NAD-dependent ADP- Ribosyltransferase Sirtuin 4, SIR2L4, Silent Information Regulator 4, Sirtuin 4)
Catalog No			USB-220267
Supplier’s Catalog No			220267
Supplier			US Biologicals
Source antigen			Recombinant, E. coli
Reactivity
Cross reactivity
Applications
Molecular weight			61.9

Storage			-70°C
Other names
Grade			Highly Purified
Purity			~95% (SDS-PAGE)
Form			Supplied as a liquid in 50mM sodium phosphate, pH 7.2, 100mM sodium chloride, 2.5mM DTT, 20% glycerol.
Reactivity life			12 months
Note			For reserch purpose only
Purity			~95% (SDS-PAGE)
Description			There are seven human sirtuins, also known as class III HDACs, which have been designated SIRT1 to SIRT7. Each is involved in various post-translational modifications by utilizing NAD dependent deacetylase and APD-ribosyltransferase activities. SIRT4 is a mitochondrial ADP-ribosyltransferase responsible for the transfer of ADP-ribose from NAD to specific substrates such as glutamate dehydrogenase (GDH). In caloric-sufficient conditions, SIRT4 ADP-ribosylates GDH, repressing its activity and correspondingly decreasing insulin secretion. There is some uncertainty about the relevance of sirtuin ribosyl transferase activity due to its very slow rate, which is about 500 times lower than the corresponding deacetylation reaction (for those that have been characterized). SIRT4 is found in many tissues, but is specifically enriched in the kidney, heart, brain, and liver. Source: Recombinant protein corresponding to human SIRT4, fused to GST-tag at N-terminal, expressed in E. coli. Molecular Weight: ~61.9kD (NT GST Tag) Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.