SIRT5, Recombinant, Human, GST-tag (NAD-dependent Deacetylase 5, SIR2-like Protein 5, SIR2L5, Sirtuin 5, Silent Information Regulator 5)
Catalog No : USB-220268
432.20€
0.00€
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| Product name | SIRT5, Recombinant, Human, GST-tag (NAD-dependent Deacetylase 5, SIR2-like Protein 5, SIR2L5, Sirtuin 5, Silent Information Regulator 5) | ||
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| Catalog No | USB-220268 | ||
| Supplier’s Catalog No | 220268 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 60.6 | ||
| Storage | -70°C | ||
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| Other names | |||
| Grade | Purified | ||
| Purity | ~90% (SDS-PAGE) | ||
| Form | Supplied as a liquid in 50mM sodium phosphate, pH 7.2, 100mM sodium chloride, 20% glycerol. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ~90% (SDS-PAGE) | ||
| Description | The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-7. SIRT5 is located in the mitochondrial matrix and its functions are largely still being elucidated, however a few promising substrates have been studied. SIRT5 has been shown to deacetylate carbamoyl phosphate synthetase 1 (CSP1), activating the enzyme to catalyze the first step of the urea cycle. CSP1 is important in the detoxification of excess ammonia that can accumulate during fasting. Cytochrome C, another mitochondrial enzyme involved in oxidative metabolism can also be deacetylated by SIRT5. SIRT5 is predominantly found in the heart, brain, testis, and lymphoblasts. Source: Recombinant protein corresponding to human SIRT5, fused to GST-tag at N-terminal, expressed in E. coli. Molecular Weight: ~60.6kD (NT GST-tag), ~26kD (native) Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | ||
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