Imugex

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Categories: Peptides & Proteins / Proteins

Product name			SIRT7, Recombinant, Human, aa2-400, His-Tag (NAD-dependent Deacetylase 7, SIR2-like Protein 7, Sirtuin 7, SIR2L7, Silent Information Regulator 7)
Catalog No			USB-220271
Supplier’s Catalog No			220271
Supplier			US Biologicals
Source antigen			Recombinant, E. coli
Reactivity
Cross reactivity
Applications
Molecular weight			49.3

Storage			-70°C
Other names
Grade			Purified
Purity			~85% (SDS-PAGE)
Form			Supplied as a liquid in 50mM Tris, pH 7.5, 150mM sodium chloride, 20% glycerol.
Reactivity life			12 months
Note			For reserch purpose only
Purity			~85% (SDS-PAGE)
Description			The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-SIRT7. Recently, SIRT7 has been shown to activate transcription by RNA polymerase I and deacetylate p53. SIRT7 prevents progressive functional deterioration of the heart, and is suggested to play an important role in regulation of stress responses and cell death in the heart. Source: Recombinant protein corresponding to aa2-400 from human SIRT7, fused to His-tag at N-terminal, expressed in E. coli. Molecular Weight: ~49.3kD (aa2-400, NT His-tag) Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.