Imugex

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Categories: Peptides & Proteins / Proteins

Product name			Sirtuin 6, Recombinant, Human, aa1-355, His-Tag (SIRT6, NAD-Dependent Deacetylase Sirtuin-6n Mono-ADP-ribosyltransferase Sirtuin 6n SIR2-like Protein 6n SIR2L6)
Catalog No			USB-301287
Supplier’s Catalog No			301287
Supplier			US Biologicals
Source antigen			Recombinant, E. coli
Reactivity
Cross reactivity
Applications
Molecular weight			45

Storage			-20°C
Other names
Grade			Highly Purified
Purity			~90% (SDS-PAGE)
Form			Supplied as a liquid in 55mM Tris-Cl, pH 8.2, 150mM sodium chloride.
Reactivity life			12 months
Note			For reserch purpose only
Purity			~90% (SDS-PAGE)
Description			Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards Lys-9 and Lys-56 of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-alpha. Source: Recombinant protein corresponding to aa1-355 of human Sirtuin 6, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~45kD Endotoxin: <0.1EU/ug (LAL method) Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.