Superoxide Dismutase 4, Recombinant, Human (SOD4, CCS, Copper Chaperone For Superoxide Dismutase, Superoxide Dismutase Copper Chaperone)
Catalog No : USB-S8060-17F
456.33€
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| Product name | Superoxide Dismutase 4, Recombinant, Human (SOD4, CCS, Copper Chaperone For Superoxide Dismutase, Superoxide Dismutase Copper Chaperone) | ||
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| Catalog No | USB-S8060-17F | ||
| Supplier’s Catalog No | S8060-17F | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E.coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 29 | ||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~95% (SDS-PAGE) | ||
| Form | Supplied as a lyophilized powder from 20mM HEPES, pH 7.4. Reconstitute with sterile dH2O PBS. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95% (SDS-PAGE) | ||
| Description | Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2-) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu,Zn-SOD/SOD1), mitochondrial manganese SOD (Mn-SOD/SOD2) and extracellular Cu, Zn-SOD (EC-SOD/SOD3) (1). SOD1 is found in all eukaryotic species as a homodimeric 32kD enzyme containing one each of Cu and Zn ion per subunit (2). The manganese containing 80kD tetrameric enzyme SOD2, is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain (3). SOD3 is a heparin-binding multimer of disulfide-linked dimers, primarily expressed in human lungs, vessel walls and airways (4). SOD4 is a copper chaperone for superoxide dismutase (CCS), which specifically delivers Cu to copper/zinc superoxide dismutase. CCS may activate copper/zinc superoxide dismutase through direct insertion of of the Cu cofactor. Source: Recombinant corresponding to aa1-274 from human Superoxide Dismutase 4, expressed in E.coli. Molecular Weight: ~29kD Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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