Syntaxin-1A, Recombinant, Human, aa1-226, His-Tag (STX1A)
Catalog No : USB-209223
531.05€
0.00€
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| Product name | Syntaxin-1A, Recombinant, Human, aa1-226, His-Tag (STX1A) | ||
|---|---|---|---|
| Catalog No | USB-209223 | ||
| Supplier’s Catalog No | 209223 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 26.1 | ||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Purified | ||
| Purity | Purified | ||
| Form | Supplied as a liquid in 20mM Tris-HCl, pH 7.5, 1mM DTT, 10% glycerol. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | Purified | ||
| Description | Syntaxin is membrane integrated Q-SNARE protein participating in exocytosis. Syntaxin is composed of an N-terminal regulatory domain (Habc), a SNARE domain (known as H3), and a single C-terminal transmembrane domain. The SNARE (H3) domain binds to both synaptobrevin and SNAP-25 forming the core SNARE complex. Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor which produces exocytosis. Source: Recombinant protein corresponding to human Syntaxin-1A, a single, non-glycosylated polypeptide chain containing 226aa (aa1-226), contains N-terminal domain (Habc) and t_SNARE domain (H3 domain), fused to His-tag at N-terminal, expressed in E. coli. Molecular Weight: ~26.1kD Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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