Synuclein, alpha, Recombinant, Human (NACP)

Catalog No : USB-S9500-39
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Product name Synuclein, alpha, Recombinant, Human (NACP)
Catalog No USB-S9500-39
Supplier’s Catalog No S9500-39
Supplier US Biologicals
Source antigen Recombinant, E. coli
Reactivity
Cross reactivity
Applications
Molecular weight 14.4
Storage -20°C
Other names
Grade Highly Purified
Purity ≥ 95% by SDS PAGE. Endotoxin: ≤1.0EU (LAL).
Form Supplied as a liquid in 20mM Tris-HCl, pH 7.5, 0.1M sodium chloride, 1mM magnesium chloride
Reactivity life 6 months
Note For reserch purpose only
Purity ≥ 95% by SDS PAGE. Endotoxin: ≤1.0EU (LAL).
Description Alpha synuclein (aa1-140), an acidic neuronal protein of 140 aa, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. Alpha synuclein has been suggested to be implicated in the pathogenesis of Parkinson’s disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Moreover, recent studies have shown that alpha synuclein has chaperone activity and that this activity is lost upon removing its C-terminal acidic tail (aa96-140). AA Sequence: MDVFMKGLSK/ AKEGVVAAAE/ KTKQGVAEAA/ GKTKEGVLYV/ GSKTKEGVVH/ GVATVAEKTK/ EQVTNVGGAV/ VTGVTAVAQK/ TVEGAGSIAA/ ATGFVKKDQL/ GKNEEGAPQE/ GILEDMPVDP/ DNEAYEMPSE/ EGYQDYEPEA Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.