Imugex

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Categories: Peptides & Proteins / Proteins

Product name			Synuclein, alpha, Recombinant, Human (Alpha-synuclein, SNCA, MGC110988, Non-A beta Component of AD Amyloid, Non-A4 Component of Amyloid Precursor, NACP, PARK1, PARK4, PD1)
Catalog No			USB-S9500-01P
Supplier’s Catalog No			S9500-01P
Supplier			US Biologicals
Source antigen			Recombinant, E. coli
Reactivity
Cross reactivity
Applications
Molecular weight			14.4

Storage			-20°C
Other names
Grade			Purified
Purity			~95% (SDS-PAGE)
Form			Supplied as a lyophilized powder from 20mM Tris-HCl buffer, pH 7.5, 100mM sodium chloride, 1mM magnesium chloride. Reconstitute in sterile dH2O at a concentration of < 1mg/ml.
Reactivity life			6 months
Note			For reserch purpose only
Purity			~95% (SDS-PAGE)
Description			Alpha-Synuclein (aa1-140), an acidic neuronal protein of 140 aa, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. Alpha- synuclein has been suggested to be implicated in the pathogenesis of Parkinson’s disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Moreover, recent studies have shown that Alpha-synuclein has chaperone activity and that this activity is lost upon removing its C-terminal acidic tail (amino acids 96-140). Sequences of Amino Acids: MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA Molecular Weight: ~14.4kD Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.