Imugex

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Categories: Peptides & Proteins / Proteins

Product name			Synuclein, alpha, Recombinant, Human (SNCA, MGC110988, Alpha-synuclein, Non-A beta Component of AD Amyloid, Non-A4 Component of Amyloid Precursor, NACP, NACP, PARK1)
Catalog No			USB-217825
Supplier’s Catalog No			217825
Supplier			US Biologicals
Source antigen			Recombinant, E. coli
Reactivity
Cross reactivity
Applications
Molecular weight			14.5

Storage			-20°C
Other names
Grade			Highly Purified
Purity			~95% (gel scan and mass spec)
Form			Supplied as a lyophilized powder in 10mM Tris-HCl, pH 7.4. Reconstitute with 500ul sterile dH2O.
Reactivity life			12 months
Note			For reserch purpose only
Purity			~95% (gel scan and mass spec)
Description			Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced transcripts of SNCA have been identified. Additional splicing may be present but the full-length nature of these variants has not been determined. Source: Recombinant protein corresponding to human alpha-synuclein, expressed in E. coli. Molecular Weight: ~14.5kD Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.