Thioredoxin 2, Recombinant, Human (Thioredoxin-2, Thioredoxin II, TR-II, Thioredoxin-1, TRX2, TRX1, YGR209C, G7746)
Catalog No : USB-T5010-15H
456.33€
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| Product name | Thioredoxin 2, Recombinant, Human (Thioredoxin-2, Thioredoxin II, TR-II, Thioredoxin-1, TRX2, TRX1, YGR209C, G7746) | ||
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| Catalog No | USB-T5010-15H | ||
| Supplier’s Catalog No | T5010-15H | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E.coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 12 | ||
| Storage | -70°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~95% (SDS-PAGE) | ||
| Form | Supplied as a liquid in 20mM HEPES, pH 7.0, 10% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95% (SDS-PAGE) | ||
| Description | Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds (1). Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations (2). Specific protein disulfide targets for reduction by Trx include protein disulfide -isomerase (PDI) (3) and a number of transcription factors such as p53 (4), NF-kB (5) and AP-1 (T1-151). Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins (6-7). Source: Recombinant corresponding to aa60-166, without mitochondrial leader sequence, from human Thioredoxin 2, expressed in E.coli. Molecular Weight: ~12kD Specific Activity: 8.2U/mg (One unit will cause a A650 of 1 in 1 min at 25°C in the insulin reduction assay) Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | ||
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