THBS1, Recombinant, Human (TSP, TSP1, THBS1, Thrombospondin-1)
Catalog No : USB-500495
624.16€
0.00€
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| Product name | THBS1, Recombinant, Human (TSP, TSP1, THBS1, Thrombospondin-1) | ||
|---|---|---|---|
| Catalog No | USB-500495 | ||
| Supplier’s Catalog No | 500495 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, Insect cells | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 140 | ||
| Storage | 4°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~95% (SDS-PAGE) | ||
| Form | Supplied as a liquid in PBS, pH 6.0. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95% (SDS-PAGE) | ||
| Description | TSP is an adhesive protein that can bind to many different cell types, including hematopoietic progenitor cells. It possesses a number of functional domains that serve as receptor recognizing regions. The amino-terminal heparin-binding domain interacts with heparin, other glycosaminoglycans and glycolipids and likely recognizes specific cell surface proteoglycans. The central disulfide cross-linked region is responsible for high affinity binding to one of the CD antigens, CD36 . TSP has been demonstrated to bind to integrin-alpha-V , integrin-beta-3 and integrin-alpha-2b, integrin-beta-3. The carboxy-terminal region of TSP also contains at least one binding epitope for a cell receptor. TSP can interact with fibrinogen and fibronectin. TSP appears to be involved intimately in the regulation of cellular proliferation. It is expressed as an early response gene following treatment of cells with various mitogens and cytokines. It modulates the progression of cells through the cell cycle. It augments the proliferative response to EGF. TSP inhibits endothelial cell chemotactic response to bFGF and reduces their proliferative response to serum and bFGF. Source: Recombinant protein corresponding to human THBS1 expressed in Insect cells. Molecular Weight: ~140kD Endotoxin: <1EU/ug (LAL) Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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