PCAF, active (p300/CBP-associated factor, CREBBP-associated factor, CAF, P/CAF)
Catalog No : USB-P3114
806.92€
0.00€
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| Product name | PCAF, active (p300/CBP-associated factor, CREBBP-associated factor, CAF, P/CAF) | ||
|---|---|---|---|
| Catalog No | USB-P3114 | ||
| Supplier’s Catalog No | P3114 | ||
| Supplier | US Biologicals | ||
| Source antigen | E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 79 | ||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Purified | ||
| Purity | ~30% | ||
| Form | Supplied as a liquid 50mM Tris-HCl, pH 8.0, 150mM sodium chloride, 25mM glutathione, 50% glycerol. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ~30% | ||
| Description | A direct link exists between hyperacetylation of chromatin and transcriptional activation. Experiments have established that PCAF possesses intrinsic histone acetylase activity. PCAF primarily acetylates lysine 14 of H3. It acetylates lysine 8 of H4 less efficiently. PCAF also acetylates p53 in response to DNA damage. The distinct patterns of acetylation by PCAF may contribute to transcriptional regulation of important genes. Source: Expressed in E. coli corresponding to aa352-832. Quality Control: HAT Assay: 500ng of PCAF was used to acetylate histones in vitro with tracer levels of [3H]AcetylCoA as the acetyl donor. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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